at Christiana Care Health System in Newark, Delaware, United States
Would you like to join a team of Scientists leading the world in Patient-First Genomic Science? If so, the Gene Editing Institute is the place to be.
The Gene Editing Institute (GEI) leads the field in advancing the science and precision of gene editing. It is the only institute of its kind embedded in a world-class community health system, ChristianaCare, and brings a unique patient focus to its work.
Led by gene editing pioneer Eric Kmiec, our extraordinary team works closely together in our state-of-the-art laboratories, developing disease-conquering therapies through breakthrough discoveries and research. We are passionate in our pursuit of science to improve the human condition.
We are searching for a highly motivated Staff Scientist II to engage in projects focused on developing innovative gene editing therapies for solid tumors, specializing in animal model research. This associate investigator will utilize laboratory animal handling experience and knowledge to work with a cross-functional team of cell and molecular biologists in a fast-paced environment within the Gene Editing Institute.
The successful candidate is expected to carry out the assigned projects mostly independently. Primary responsibilities include but are not limited to designing, optimizing, executing, and troubleshooting in-vivo mouse studies focused on developing innovative gene editing therapies for solid tumors.
Additional duties to include:
Participate in preclinical research utilizing laboratory animals maintained in a research facility
Write IACUC protocols and support amendments
Perform major and minor surgical procedures: Subcutaneous and orthotopic model development, intratumoral / tail vein / intraperitoneal injection, tumor removal.
Analyze collected tumors and tissues for molecular biology protocols such as RNA and DNA purification, PCR, and Sanger sequencing
Collect, submit, analyze, preserve, and dispose of biological specimens, and perform euthanasia and necropsy of experimental animals.
Perform cleaning (to include surgical areas), disinfection, sterilization, and packing of surgical instruments
Provide animal health care in accordance with the Guide for the Care and Use of Laboratory animals, vivarium standing operating procedures, and the Attending Veterinarian.
Independently maintain various types of adherent and suspension mammalian cell cultures in a sterile environment
Maintain a highly organized, technical, and detailed laboratory notebook
Present research findings, including preparation of research reports and abstracts, dissemination at national and international scientific conferences and publication of manuscripts by peer-reviewed scientific journals.
Perform assigned work safely, adhering to established departmental safety rules and practices; report to Group leader, in a timely manner, any unsafe activities, conditions, hazards, or safety violations that may cause injury to oneself, other employees, patients and visitors.
Bachelor's degree in animal science, molecular biology, biochemistry, biological sciences, or related field with 3 - 7 years of work experience or MS with 0 - 4 years of work experience
Experience with laboratory animal handling
Experience with wide variety of molecular biology techniques
Experience in molecular biology assay development
Experience in mammalian cell culture
Experience with managing multiple projects simultaneously
Experience in fast-paced biotechnology industry is preferred
Basic knowledge and technical skill in molecular biology
Knowledge in CRISPR gene editing is preferred
Experienced in cancer biology/genetics is preferred
Strong troubleshooting and problem-solving skills
Ability to incorporate new methods to improve various aspects of workflows
Skilled in data organization and management
Ability to effectively work independently and as part of a team
Skilled in effective communication and reporting with team members and supervisors
Compensation & benefits package include:
Health, dental and vision benefits
Generous Paid Time Off
403b and Defined Contribution Plans
12 weeks paid parental leave
ChristianaCare is one of the country's most dynamic health systems, centered on improving health outcomes, making high-quality care more... For full info follow application link.
Christiana Care Health System is an equal opportunity employer, firmly committed to prohibiting discrimination, whose staff is reflective of its community, and considers qualified applicants for open positions without regard to race, color, sex, religion, national origin, sexual orientation, genetic information, gender identity or expression, age, veteran status, disability, pregnancy, citizenship status, or any other characteristic protected under applicable federal, state, or local law.