Staff Scientist - Preclinical Study in Animal Mode

at Christiana Care Health System in Newark, Delaware, United States

Job Description

Would you like to join a team of Scientists leading the world in Patient-First Genomic Science? If so, the Gene Editing Institute is the place to be.

The Gene Editing Institute (GEI) leads the field in advancing the science and precision of gene editing. It is the only institute of its kind embedded in a world-class community health system, ChristianaCare, and brings a unique patient focus to its work.

Led by gene editing pioneer Eric Kmiec, our extraordinary team works closely together in our state-of-the-art laboratories, developing disease-conquering therapies through breakthrough discoveries and research. We are passionate in our pursuit of science to improve the human condition.

We are searching for a highly motivated Staff Scientist II to engage in projects focused on developing innovative gene editing therapies for solid tumors, specializing in animal model research. This associate investigator will utilize laboratory animal handling experience and knowledge to work with a cross-functional team of cell and molecular biologists in a fast-paced environment within the Gene Editing Institute.

The successful candidate is expected to carry out the assigned projects mostly independently. Primary responsibilities include but are not limited to designing, optimizing, executing, and troubleshooting in-vivo mouse studies focused on developing innovative gene editing therapies for solid tumors.

Additional duties to include:

Participate in preclinical research utilizing laboratory animals maintained in a research facility

Write IACUC protocols and support amendments

Perform major and minor surgical procedures: Subcutaneous and orthotopic model development, intratumoral / tail vein / intraperitoneal injection, tumor removal.

Analyze collected tumors and tissues for molecular biology protocols such as RNA and DNA purification, PCR, and Sanger sequencing

Collect, submit, analyze, preserve, and dispose of biological specimens, and perform euthanasia and necropsy of experimental animals.

Perform cleaning (to include surgical areas), disinfection, sterilization, and packing of surgical instruments

Provide animal health care in accordance with the Guide for the Care and Use of Laboratory animals, vivarium standing operating procedures, and the Attending Veterinarian.

Independently maintain various types of adherent and suspension mammalian cell cultures in a sterile environment

Maintain a highly organized, technical, and detailed laboratory notebook

Present research findings, including preparation of research reports and abstracts, dissemination at national and international scientific conferences and publication of manuscripts by peer-reviewed scientific journals.

Perform assigned work safely, adhering to established departmental safety rules and practices; report to Group leader, in a timely manner, any unsafe activities, conditions, hazards, or safety violations that may cause injury to oneself, other employees, patients and visitors.


Bachelor's degree in animal science, molecular biology, biochemistry, biological sciences, or related field with 3 - 7 years of work experience or MS with 0 - 4 years of work experience

Experience with laboratory animal handling

Experience with wide variety of molecular biology techniques

Experience in molecular biology assay development

Experience in mammalian cell culture

Experience with managing multiple projects simultaneously

Experience in fast-paced biotechnology industry is preferred

Additional requirements:

Basic knowledge and technical skill in molecular biology

Knowledge in CRISPR gene editing is preferred

Experienced in cancer biology/genetics is preferred

Strong troubleshooting and problem-solving skills

Ability to incorporate new methods to improve various aspects of workflows

Skilled in data organization and management

Ability to effectively work independently and as part of a team

Skilled in effective communication and reporting with team members and supervisors

Compensation & benefits package include:

Competitive salary

Health, dental and vision benefits

Generous Paid Time Off

403b and Defined Contribution Plans

12 weeks paid parental leave

About ChristianaCare:
ChristianaCare is one of the country's most dynamic health systems, centered on improving health outcomes, making high-quality care more... For full info follow application link.

Christiana Care Health System is an equal opportunity employer, firmly committed to prohibiting discrimination, whose staff is reflective of its community, and considers qualified applicants for open positions without regard to race, color, sex, religion, national origin, sexual orientation, genetic information, gender identity or expression, age, veteran status, disability, pregnancy, citizenship status, or any other characteristic protected under applicable federal, state, or local law.

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Job Posting: 996785

Posted On: Jul 01, 2022

Updated On: Jul 31, 2022