Staff / Sr Staff Scientist, DMPK

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our Discovery Biology function is looking for a motivated scientist in our Pharmacokeinetics group. This position will be responsible for maintaining the schedule and prepare doses for Discovery pharmacokinetic studies and conducts in vitro ADME assays including bioanalytical analysis using LC-MS/MS.
Essential Functions of the Job (Key responsibilities)
Work closely with medicinal chemists and DMPK scientists to formulate research compounds for weekly pharmacokinetic studies.
* Prepare Discovery PK Study Request forms, Dose Preparation sheets and review protocols for contracted studies.
* Schedule and manage Discovery Pharmacokinetic studies in-house and with CROs.
* Review and process work orders and invoices for contracted studies.
* Perform general lab functions; preparing buffers, organizing test articles, ordering consumables, etc.
Conduct in vitro ADME assays including INCL, protein binding, CYP inhibition, etc. when needed. Analyze samples using LC-MS/MS. Report data to Discovery teams.
Qualifications (Minimal acceptable level of education, work experience, and competency)
* Bachelor's degree in Biology, Life Science, or General Chemistry with 1 - 5 years of laboratory experience. Will consider recent a graduate with an exceptional CV.
* Competency in Microsoft Excel and Microsoft Word.
* Experience operating analytical balances and manual pipettes.
* Demonstrate attention to detail.
* Ability to work independently.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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Job Posting: 976232

Posted On: May 23, 2022

Updated On: Jun 12, 2022