Research / Sr. Research Scientist, DMB

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Job Summary (Primary function)
The position of Research/Sr Research Scientist in the DMPK group at Incyte supports the small molecule bioanalysis of study samples from pharmacokinetic, toxicokinetic, PK-PD, and ADME studies using LC-MS/MS in a non-regulated setting.
Essential Functions of the Job (Key responsibilities)

Routine, de novo, small molecule, Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) bioanalytical method development of assays with sub-nanomolar LLOQs in blood-plasma, using protein precipitation, liquid-liquid, or SPE extraction techniques
Analysis of study samples from pharmacokinetic studies in preclinical species dosed discretely or in cassette with rapid turnaround and high quality for lead optimization, on a routine basis
Homogenization and analysis of biological tissues supporting pharmacology and ADME studies
Bioanalysis of samples from toxicokinetic studies ahead of GLP tox with high quality
Calculation of pharmacokinetic parameters using standard software packages
Good understanding of ADME concepts
Understanding of GLP concepts
Independently analyze, document, summarize and report data (orally, as needed)
Write/contribute to reports for regulatory filings, as needed
Peer review of study records
Provide training to junior scientists, as required
Experience with SCIEX Analyst software
Proficiency in Microsoft office suite including Word, Excel, and PowerPoint
Flexible in a fast-paced environment
Intrinsically motivated
Preferred skills

Previous experience developing bioanalytical methodology for endogenous biomarkers
Experience with or knowledge of IDBS eWorkbook (or other ELN), Thermo Fisher Watson LIMS
GLP experience
Programming and/or operation of Hamilton STAR robotic liquid handler
Qualifications (Minimal acceptable level of education, work experience, and competency)

BS/MS degree or equivalent in Life Sciences or related discipline
At least 7 years (BS) /5 years (MS) related DMPK experience in pharmaceutical companies or CROs.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.        

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Job Posting: 972764

Posted On: May 17, 2022

Updated On: Jun 05, 2022