at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our Discovery Chemistry group is looking for a Computational Chemist. The Research Investigator, Computational Chemistry is responsible for structure/ligand based drug design to support ongoing medicinal chemistry projects.
Essential Functions of the Job (Key responsibilities)
Apply structure/ligand-based design, molecular docking and pharmacophore models to assist the medicinal chemistry teams in prioritizing compound design.
Develop computational methods or workflows to support the drug discovery projects
Collaborate with project team members to analyze scientific data
Apply computational methods to search and evaluate potential new targets
Qualifications (Minimal acceptable level of education, work experience, and competency)
PhD in Computational Chemistry or related fields. Post-doctoral experience is preferred.
Strong track record of external publications and presentations demonstrating scientific innovation in structure based drug discovery and protein modelling is essential.
Expertise in common computer programming and scripting languages (ie Python, C#, Java, etc) is essential
Expertise in several modeling methods, and familiarity with others is essential (docking, molecular dynamics simulation, free energy calculations, homology modeling, large scale data analysis and visualization, multi-parameter optimization, QSAR, machine learning, cheminformatics)
Familiarity with one or more commercial computational chemistry packages is preferred (Schrodinger Maestro, CCG MOE, OpenEye, KNIME)
Excellent communication skills and the ability to work well within a multi-disciplinary team are required
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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