at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Research Investigator/Sr. Research Investigator, Antibody Pharmacology
This individual will work as part of antibody pharmacology team focusing on in vivo target validation and proof of concept, as well as novel target identification. A successful candidate will be able to utilize the appropriate syngeneic and humanized mouse models to provide pharmacological insight into mechanism of action of various biologics. The candidate should also have experience in developing in vitro and ex vivo assays and a deep knowledge of technologies commonly used to assess immune endpoints.
Identify, design, and utilize the appropriate in vivo model systems to demonstrate proof of concept and address key biological questions
Design and execute in vitro experiments to determine the functional effect(s) of candidate target activation/inhibition by using a variety of assays to interrogate immune end-points
Collaborate with other functional groups within drug discovery to achieve key goals
Research potential new antibody targets and present to management for consideration as early discovery programs
Effectively coordinate with CRO or external collaboration to evaluate potential clinical candidates
Generate written reports and powerpoint presentation periodically
Ph.D. in Immunology, Pharmacology, or related field
Post-doctoral experience in a relevant field
Pharmaceutical or biotech experience preferred, but not required
Experience with in vivo models of cancer
Expertise in a variety of immunological assays including flow cytometry, functional and molecular assays
Excellent communication skills and a solid publication record
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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