Research Investigator, Cell Line Development

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Our BioPharmaceutical Development group is looking for a Research Investigator, Cell Line Development. The Research Investigator, who has a molecular biology and cell culture development experience will be responsible for developing commercially viable cell lines that are used in the production of therapeutic recombinant proteins such as fusion protein, monoclonal and bispecific antibodies.

Essential Functions of the Job (Key responsibilities)

Perform transfection, routine cell culture work, including cell passage and secure freeze.

Operate amber15 for Fed-batch study.

Evaluate CHO host and vector technologies of in-house licensed and new CRO technologies to establish platform for mAb production.

Design and execute high throughput assays to screen mAb or BsAb minipools and clones, ensure production, product quality.

Design and conduct genetic stability of cell lines.

Qualify single cell plating and imaging workflow to ensure that monoclonality assessments meet regulatory expectations.

Perform clone genetic stability study.

Oversee the creation and maintenance of research cell banks as well as Master and Working Cell Banks manufactured and tested at Contract Labs.

Present data summaries and study conclusions at internal scientific meetings.

Train junior staff scientist.

Ensure all work is appropriately documented in electronic lab notebook and reports are written in timely manner.


Qualifications (Minimal acceptable level of education, work experience, and competency)

Doctoral degree with 2-5 years relevant experience and/or Masters' degree with 5-10 years relevant experience and/or Bachelors' degree in Biopharmaceuticals plus 10 years' relevant experience in molecular or cell biology, chemical engineering, or related field.

Prefer at least 3 years' experience in developing high titer CHO cell lines expressing recombinant proteins such as fusion protein, monoclonal antibody, bispecific antibody.

Experience with molecular biology, such as Vector construction, Restriction. digestion/purification plasmids, extraction of gDNA or RNA from CHO cells.

Experience with Vector NTI, and Sequencher software.

Experience with high throughput techniques in 384 and/or 96 well plate format such as Octet, ELISA, Guava, SDS-PAGE, ProA Spin-Column purification etc.

Experience with statistical Design of Experiment is a plus.

Strong written and verbal communication and organization skills are required.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.        



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Job Posting: 859931

Posted On: Oct 19, 2021

Updated On: Nov 06, 2021