at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Translational Sciences at Incyte has been established to bridge the research findings at the Discovery and Development levels within each of our clinical programs. In collaboration with academic, clinical and industry scientists, this group develops knowledge around each of our existing programs to enable clinical evaluation of target modulation, biological changes that correlate with target modulation, as well as biomarkers or patient characteristics that could be utilized to predict response to therapy. The results are used to enrich and refine the Development program strategy as well as inform and guide future Discovery efforts.
Summary (Primary function)
The Research Scientist/Sr Research Scientist, Translational Sciences (TLS), will develop and implement specialized molecular, cellular and biochemical assays to support specific portfolio related hypotheses and biomarker development. We are looking for a highly motivated scientist to work in a collaborative laboratory environment to discover and develop robust biomarkers for use in human clinical studies.
Essential Functions of the Job (Key responsibilities)
Develop, optimize, and qualify pharmacodynamic and target engagement biomarker assays.
Independently manage workload across multiple projects while effectively aligning resources based on key priorities.
Assimilate data and insight in real-time to recognize when an experimental approach needs to be adjusted/changed to deliver optimal results.
Troubleshoot and overcome complex problems in specialized procedures.
Incorporate proper quality controls and best practices to produce high-quality work.
Keep current with emerging trends in scientific discipline.
Understands the role of other functional areas in the laboratory and partners with them to maximize best practices and laboratory efficiencies.
Follow company safety practices, including training, lab safety, and record keeping as appropriate.
Qualifications (Minimal acceptable level of education, work experience, and competency)
Bachelor's Degree or equivalent education and typically 7 or more years of experience, Master's Degree or equivalent education and typically 5 or more years of experience.
Extensive experience with assay development using various molecular, cellular and biochemical assays (e.g. flow cytometry, ELISA, MSD, qPCR, ddPCR, and Western Blotting).
Experience with automated DNA/RNA extraction along with appropriate QC methods.
Expertise in NGS library preparation and sequencing, most commonly RNAseq or 10X Genomics single cell libraries.
Experience with transcriptomic/genomic data analysis tools/databases
Strong scientific background with practical experience, and excellent verbal and written communications skills
Self-motivated and highly organized with ability to work on multiple projects.
Strong computer skills are essential.
Excellent interpersonal skills, able to work in a team-oriented environment.
Solid understanding of cancer biology and/or immuno-oncology is highly desirable
Experience with lab automation or operation of liquid handlers.
Experience with advanced single-cell techniques such as CITE-seq and scATAC.
Experience with ex vivo culture of human tissues, cell biology/flow cytometry techniques and/or ligand binding assays is a plus
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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