at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our Discovery Chemistry group is looking for a Computational Chemist. The Research Investigator, Computational Chemistry is responsible for structure-based drug design and cheminformatics to support ongoing medicinal chemistry projects.
Essential Functions of the Job (Key responsibilities)
Apply structure/ligand-based design, molecular docking and pharmacophore models to evaluate and improve potency of the lead compounds
Apply computational methods for in-silico evaluation of potential new targets
Implement cheminformatics solutions to support the Discovery Chemistry projects
Collaborate with project team members to analyze scientific data
Qualifications (Minimal acceptable level of education, work experience, and competency)
PhD in Computational Chemistry or related fields. Post-doctoral experience is preferred.
1-3 years of experience protein modeling and homology modeling.
Strong track record of external publications and presentations demonstrating scientific innovation in structure based drug discovery and protein modelling is essential.
Expertise in common computer programming and scripting languages (ie Python, C#, Java, etc) is essential
Expertise in several computational methods, and familiarity with others is essential (docking, molecular dynamics simulations, free energy simulations, homology modeling, large scale data analysis and visualization, multi-parameter optimization, QSAR)
Excellent communication skills and the ability to work well within a multi-disciplinary team are required
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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