Principal Investigator, Pharmacology

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Principal Investigator, Oncology Discovery

Job Summary (Primary function)

Incyte Discovery is seeking a highly motivated and accomplished Cancer Biologist to play a key role in advancing an innovative Oncology / Immuno-Oncology drug discovery pipeline. The successful candidate will support the identification and validation of novel cancer targets and have the opportunity to lead small molecule drug discovery programs. The candidate is expected to be knowledgeable in the application of cutting-edge molecular, cellular, genetic and pharmacological techniques to develop preclinical disease models. Using a broad range of innovative approaches, the candidate is expected to provide deep mechanistic understanding of the target biology and determine the effects of investigational agents. Additionally, the candidate will have the opportunity to support current clinical stage development programs and to work with external collaborators to advance the Discovery pipeline. The successful candidate is expected to be a team player with demonstrated ability to lead multidisciplinary scientific project teams in a drug discovery setting.

Essential Functions of the Job (Key responsibilities)


Independently design, execute, analyze and present research findings to internal and external audiences.


Develop disease-relevant preclinical models to address mechanistic questions of target biology.


Provide cross-departmental scientific leadership on cancer drug discovery programs from initiation to the selection of clinical candidate(s).


Manage multiple projects and collaborate effectively with stakeholders across the Organization.


Supervise and manage the activities of research associates.


Propose and champion new drug targets, pathways or genomic screens for consideration.

Qualifications (Minimal acceptable level of education, work experience, and competency)


Ph.D. and at least 5 years of relevant post-doctoral or industry experience in Cancer Cell Biology, Cancer Genetics, Tumor Immunology, or related field


Competitive candidates are expected to have a strong track-record of independent and innovative research as evidenced by publications in top tier scientific journals and/or presentations at scientific conferences.


Demonstrated success in contributing and advancing early drug discovery programs through to the identification of clinical candidates.


Proficient in computational tools and genomic data analysis (e.g. TCGA, DepMap, etc) is desired.


Proven experience in leading team(s) of peers and in mentoring junior scientists.


Outstanding written and oral communication skills.


Excellent interpersonal skills and ability to work in a fast-paced and dynamic environment.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.        



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Job Posting: 823430

Posted On: Jul 16, 2021

Updated On: Aug 15, 2021