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Postdoctoral Researcher - Function & Structure of RNA-Modify

at University of Delaware in Newark, Delaware, United States

Job Description

Postdoctoral Researcher – Function & Structure of RNA-Modifying Enzymes

Apply now (https://secure.dc4.pageuppeople.com/apply/858/gateway/default.aspx?c=apply&lJobID=496575&lJobSourceTypeID=796&sLanguage=en-us) Job no: 496575

Work type: Staff

Location: Newark

Categories: Research & Laboratory, Full Time

Postdoctoral Researcher, Function & Structure of RNA-Modifying Enzymes

The Mugridge lab (mugridgelab.org) in theDepartment of Chemistry & Biochemistry (https://www.chem.udel.edu/) at the University of Delaware is seeking a postdoctoral researcher to join our team. Our lab is focused on a mechanistic, structure-level understanding of how cellular RNA-modifying enzymes control diverse chemical modifications on mRNA and tRNA to affect RNA structure, processing, translation, and stability, and impact human disease.We are looking for an enthusiastic, self-motivated postdoc to lead a project studying the biochemistry and structural biology of mRNA-modifying enzymes; this project is fully NIH-funded with the flexibility to explore different scientific directions and ideas.

Preferred Candidates

We welcome applications from scientists of all backgrounds who are excited about understanding how protein-protein and protein-RNA interactions regulate RNA modification and function. The ideal candidate will have a PhD in biochemistry, structural biology, molecular biology, or a related field, and have experience with protein expression and purification from bacterial and eukaryotic expression systems, in vitro and/or cell-based biochemical assays, and macromolecular structural and/or biophysical techniques. Applicants with experience studying protein-nucleic acid interactions are particularly encouraged to apply. The successful applicant will also have a strong scientific record, excellent communication skills, ability to work independently and as part of team, and willingness to help mentor junior scientists.

Our Lab

The Mugridge lab combines techniques from biochemistry, structural biology, biophysics, and chemical biology to determine the structural and molecular mechanisms that regulate the dynamic chemical modification landscape of RNA, or the ‘epitranscriptome’. Our lab houses brand new instrumentation for macromolecular protein function and structure work including an AKTA Pure 25M FPLC, Agilent 1260 Infinity II bio-inert UHPLC with iQMS mass spectrometer, Zeiss V20 stereomicroscope and other equipment for protein crystallography, and new infrastructure to support diverse biochemical and molecular biology techniques. We are part of a multidisciplinaryNIH COBRE center (https://www.udel.edu/udaily/2020/november/biomedical-research-cobre-joseph-fox-infectious-disease-cancer/) at UD and have ready access to state-of-the-art core facilities including proteomics/mass spectrometry, protein crystallography, NMR, cell imaging and microscopy, and DNA/RNA sequencing cores. The University of Delaware is an R1 research University located in the heart of the mid-Atlantic region, nearby to Philadelphia, Baltimore, coastal beaches, and within easy driving distance of NYC and Washington DC.

Apply or ask!

To apply, please submit a one-page cover letter, a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references. Applications will be evaluated on a rolling basis. If interested, feel free to email Jeff (mugridge@udel.edu) with any questions.

Notice of Non-Discrimination, Equal Opportunity and Affirmative Action

The University of Delaware does not discriminate against any person on the basis of race, color, national origin, sex, gender identity or expression, sexual orientation, genetic information, marital status, disability, religion, age, veteran status or any other characteristic protected by applicable law in its employment, educational programs and activities, admissions policies, and scholarship and loan programs as required by Title IX of the Educational Amendments of 1972, the Americans with Disabilities Act of 1990, Section 504 of the Rehabilitation Act of 1973, Title VII of the Civil Rights Act of 1964, and other applicable statutes and University policies. The University of Delaware also prohibits unlawful harassment including sexual harassment and sexual violence.

Notice of Non-Discrimination, Equal Opportunity and Affirmative Action

The University of Delaware does not discriminate against any person on the basis of race, color, national origin, sex, gender identity or expression, sexual orientation, genetic information, marital status, disability, religion, age, veteran status or any other characteristic protected by applicable law in its employment, educational programs and activities, admissions policies, and scholarship and loan programs as required by Title IX of the Educational Amendments of 1972, the Americans with Disabilities Act of 1990, Section 504 of the Rehabilitation Act of 1973, Title VII of the Civil Rights Act of 1964, and other applicable statutes and University policies. The University of Delaware also prohibits unlawful harassment including sexual harassment and sexual violence.

Applications close:

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Job Posting: JC187695063

Posted On: Jul 14, 2021

Updated On: Dec 03, 2021