Sr. Research Investigator/Principal Investigator *

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary

We are seeking an experienced biochemist to join our Applied Technology Division at Incyte Research Institute to drive early drug discovery. The ideal candidate should have hands-on laboratory research experience focusing on one or more of the following areas, biochemistry, biophysics, enzymology or chemical biology. The candidate should have deep interest in applying both the theoretical and practical aspects of biochemistry and/or enzymology in drug discovery. In addition to scientific qualifications, candidates with a growth mindset, a can-do attitude, team-working behaviors, and effective communication skills, will succeed and excel in this role.

Key Job responsibilities


Design, develop and execute biochemical and biophysical assays to support target based hit identification, hit qualification and lead optimization


Provide molecular mechanistic insights and guidance to lead optimization teams


Interact and collaborate effectively with both internal and external partners to progress projects towards milestones, including but not limited to, medicinal chemistry group, preclinical pharmacology group, and biologics group etc


Prepare and write technical reports to support drug candidate nomination, internal and external presentations and publications


Contribute to lead discovery and lead-optimization strategies for new targets


Seek, evaluate and implement new technologies and capabilities to increase speed and quality of early drug discovery


Potential to lead early drug discovery projects



PhD in biochemistry/biophysics/enzymology/chemical biology, with 1-3 years of independent post-doctoral research and 3+ years of industrial drug discovery experience, or equivalent


Hands-on experience and fundamental understanding of the working theories of biochemical and biophysical assays, including labelled and label-free technologies. Knowledge with mass spectrometry based methods is a plus


Critical understanding of protein/enzyme working principles, including enzyme kinetics (steady state and pre-steady state), enzyme catalytic mechanism, and ligand-induced conformational and population dynamics, and ability to reduce data into mechanistic models to help drive small molecule prioritization and optimization


Experience with data analysis software, such as Prism, XL fit, Genedata. Familiarity with data visualization tools such as Spotfire is a plus


Project leadership experience is a plus

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.        



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Job Posting: 822044

Posted On: Jul 12, 2021

Updated On: Aug 11, 2021