at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our Global BioPharmaceutical Development group is looking for a Research Scientist, Purification Process Sciences.The protein purification scientist will support protein purification process development and optimization primarily for novel therapeutic monoclonal antibody products including bispecifics throughout all stages of clinical trials.
Essential Functions of the Job (Key responsibilities):
Conduct routine protein purification to support discovery team's material needs and cell culture development.
Conduct high-throughput protein purification to support cell line development.
Conduct purification process development, optimization, and pilot scale-up manufacturing.
Conduct routine analyses of in-process samples using relevant product purity and process impurity analytical tools.
Prepare buffers and solutions needed for laboratory work.
Manage laboratory supplies and instrument maintenance.
Write routine electronic laboratory notebook and development reports.
Participate and present updates in routine group meetings.
Qualifications (Minimal acceptable level of education, work experience, and competency):
BS or MS. degree in biochemistry, bioengineering, biology, chemistry or related fields with a minimum of 2 years of relevant industry experiences.
Good knowledge in protein chemistry and bioprocessing.
Good knowledge and hands-on experiences in various types of column/membrane chromatography (affinity, size exclusion, ion exchanges, HIC, multi-mode) and filtration technology (TFF and nanofiltration) for cell culture clarification, protein purification and analysis.
Experiences in protein purification process development and scale-up.
Experiences in using AKTA line of purification instruments from lab scale to pilot scale.
Experiences in using UF/DF instrument for buffer exchange, product concentration, and formulation.
Experiences in using depth filtration for cell culture clarification.
Experiences in using analytical instruments for protein analysis such as HPLC, SoloVPE, SDS-PAGE or SDS-CGE, ELISA, etc.
Good verbal and written communication skills.
Organized, cooperative, independent, meticulous.
Experiences in Design Of Experiment approach and high-throughput protein purification platform will be a plus.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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1801 Augustine Cutoff
Wilmington, Delaware 19803