at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Translational Sciences at Incyte has been established to bridge the research findings at the Discovery and Development levels within each of our clinical programs. In collaboration with academic, clinical and industry scientists, this group develops knowledge around each of our existing programs to enable clinical evaluation of target modulation, biological changes that correlate with target modulation, as well as biomarkers or patient characteristics that could be utilized to predict response to therapy. The results are used to enrich and refine the Development program strategy as well as inform and guide future Discovery efforts.
Summary (Primary function)
The Research Scientist/Sn Research Scientist, Translational Sciences (TLS), will develop and implement specialized tissue-based assays (including multiplex assays and image analysis) to support specific portfolio related hypotheses and biomarker development. The successful candidate will manage the day-to-day operations of the IHC laboratory and perform image processing and analysis. We are looking for a highly motivated scientist to work in a collaborative laboratory environment to discover and develop robust biomarkers for use in human clinical studies.
Essential Functions of the Job (Key responsibilities)
Develop and execute histopathology assays including single and multiplex immunohistochemistry (IHC), in situ hybridization (ISH), both colorimetric and fluorescent, and other emerging techniques using our automated platforms.
Perform image analysis and quantification to characterize target expression, interrogate tumor microenvironment and aid in tissue based biomarker identification.
Work as part of a cross functional team to provide tissue-based assay development for target qualification, pharmacodynamic and efficacy readouts, and biomarker development.
Demonstrate a high level of scientific independence in the planning and execution of complex laboratory assignments at the project level.
Independently manage workload across multiple projects while effectively aligning resources based on key priorities.
Assimilate data and insight in real-time to recognize when an experimental approach needs to be adjusted/changed to deliver optimal results.
Troubleshoot and overcome complex problems in specialized procedures.
Incorporate proper quality controls and best practices to produce high-quality work.
Develop a reputation as an insightful and impactful scientist by preparing and presenting comprehensive technical or project reports and giving formal presentations to internal audience.
Keep current with emerging trends in scientific discipline.
Understands the role of other functional areas in the laboratory and partners with them to maximize best practices and laboratory efficiencies.
Completes all assigned laboratory duties in a timely manner and effectively resolves technical issues.
Follow company safety practices, including training, lab safety, and record keeping as appropriate.
Qualifications (Minimal acceptable level of education, work experience, and competency)
B.Sc., M.Sc. or Ph.D. in molecular biology, cellular biology or related subject area with 5+ years of experience.
Experience with standard histology procedures including processing and embedding human and mouse tissue, sectioning, H&E staining and other specialty stains.
Significant hands-on experience in a variety of pathology-based methodologies including IHC, multiplex IHC, ISH, immunofluorescence imaging, and digital pathology/image analysis.
Strong scientific background with practical experience, and excellent verbal and written communications skills
Self-motivated and highly organized with ability to work on multiple projects.
Strong computer skills are essential.
Excellent interpersonal skills, able to work in a team-oriented environment.
Four or more years' experience in molecular pathology in an industry setting.
Proficient at IHC assays for single-plex chromogenic and fluorescence, as well as multi-plex... For full info follow application link.
We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.
1801 Augustine Cutoff
Wilmington, Delaware 19803