Sr. Principal Investigator, Chemistry

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Overview   Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules. Job Summary (Primary function) The Senior Principal Investigator I, Chemistry designs and synthesizes novel compounds that meet nomination criteria. Essential Functions of the Job (Key responsibilities) Designs novel core structures/key structural elements for a new project based on HTS leads or published literature compounds. Drives research projects, demonstrates the ability to formulate hypothesis based on experimental SAR data, proposes strategies and designs novel molecular targets to solve key medicinal chemistry issues related to potency, selectivity and ADME properties. Analyze FTO search report and work with a patent agent to formulate patent application filing strategies and designs appropriate experiments, provides suitable data for patent applications (including a well-documented laboratory notebook). Publish in peer-reviewed journals and meet inventorship criteria as co-inventor on multiple patent applications. Present research results clearly to the department, other disciplines and at outside scientific conferences. Design/conduct organic chemistry experiments to develop and optimize the synthesis of novel compounds. Qualifications (Minimal acceptable level of education, work experience, and competency) Ph.D. in Organic Chemistry or equivalent experience. 5-7 years of related medicinal chemistry experience. Understands basic patent law. Successful track record of demonstrating the technical skills to independently design novel core structure(s) for the new project(s) based on HTS leads or published literature compounds resulting in patent applications. Life-long learner: leverage extensive use of the literature to increase knowledge base in all aspects of medicinal and organic chemistry. Follows the safety rules and maintains a safe working environment. Team player: able to work with others in their group, department and company towards the common goal of inventing novel medicines and positively influences the culture of the group.   Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required. Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer. We Respect Your Privacy Learn more at: The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.   During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process . You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work. You can learn more about Incyte's data protection practices . By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable). Please contact if you have any questions or concerns or would like to exercise your rights.   We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.  


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Job Posting: 1260017

Posted On: Apr 16, 2024

Updated On: Apr 19, 2024

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