at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our team is looking for a Research Investigator/Sr. Research Investigator in chemoproteomics. This position will be responsible for performing high resolution mass spectrometry based proteomics analysis to characterize small molecule-protein and protein-protein interactions as well as protein degradations. Extensive experience in proteome sample preparation and expertise in high-resolution mass spectrometry and proteomics applications (Q-TOF and/or Orbitrap) is required. The successful candidate will work closely with medicinal chemists, structural biologists, biochemists and computational chemists to help early drug discovery projects.
Develop and implement various types of chemoproteomics methods to investigate small molecule-protein interactions including but not limited to targeted/non-targeted proteomics.
Develop and optimize sample preparation methods for bottom-up proteomics workflows.
Develop experiments to validate results from broad screening results.
Integrate into early drug discovery projects and provide covalent fragment screening hits.
Provide documentation, analysis, interpretation, and presentation of experimental data in a clear and concise manner.
Operate, maintain and troubleshoot LC-MS instrumentation in compliance with all safety rules and procedures.
Ph.D. in Biochemistry, Chemical Biology or from a related field with 2+ years of relevant experience or a MSc degree with 10+ years of relevant experience
Expertise in proteomics methods to analyze modifications on targeted or global proteins, including but not limited to tagging, derivatization, enrichment, MS/MS fragmentation, identification and quantification.
Hands on experience with proteomics data acquisition and interpretation including data processing, deconvolution, de novo sequencing.
Strong publication record demonstrating achievements and scientific productivity.
Ability to work in a fast paced environment with strong teamwork and communication skills.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
We Respect Your Privacy
Learn more at:
The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.
During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process .
You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work.
You can learn more about Incyte's data protection practices . By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).
Please contact email@example.com if you have any questions or concerns or would like to exercise your rights.
We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.