Research/Sr. Research Scientist, in-vitro Pharmaco

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
The Sr. Research Scientist is responsible for performing in-vitro studies for cancer drug discovery programs. This includes developing relevant pre-clinical model systems to identify and validate novel therapeutic targets. The successful candidate is expected to work with minimal supervision in most molecular and cellular biology techniques and demonstrates an understanding of cancer biology. Experience with oncogenic signaling pathways and targeted therapies is an advantage. The candidate is expected to work with their supervisor to design and execute a research plan to answer critical questions about compounds and targets under evaluation.
Essential Functions of the Job (Key responsibilities)
Independently design, execute and interpret cell-based assays for small and large molecule discovery.
Familiar with small molecule screening initiatives for exploratory and lead optimization programs.
Ability to maintain accurate and detailed records of experiments, evaluate data, prepare reports and presentations for internal meetings in a timely manner.
Should be proficient at reviewing the relevant scientific literature to build protocols using Pubmed and other resources.
Collaborate with other functional groups within drug discovery to achieve shared goals.
Flexibility to acquire additional competencies and skillsets as needed.
Should be highly independent and organized, with excellent verbal and written communication skills.
Qualifications (Minimal acceptable level of education, work experience, and competency)

Bachelor's or master's degree in molecular/cell biology or related fields with 3 years of drug discovery experience.
Hands-on experience in cell culture and cell-based assays for compound screening using platforms such as ELISA, HTRF, MSD, and CTG.
Hands-on experience in standard molecular biology techniques, including Western Blotting, RT-qPCR, and gene-editing techniques (RNAi, CRISPR).
Experience in the ex-vivo culture of human tissues, immune cell separation using magnetic beads, and flow cytometry.
Working knowledge of CyTOF mass cytometry is desired.
Experience working with the hematopoietic system, including hematopoietic stem cell biology and/or hematological malignancies is a plus.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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Job Posting: 1073992

Posted On: Nov 17, 2022

Updated On: Dec 17, 2022

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