at Incyte Corporation in Wilmington, Delaware, United States
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our team is looking for a Research Investigator/Sr. Research Investigator in chemoproteomics. This position will be responsible for performing high resolution mass spectrometry based proteomics analysis to characterize small molecule-protein and protein-protein interactions as well as protein degradations. Extensive experience in proteome sample preparation and expertise in high-resolution mass spectrometry and proteomics applications (Q-TOF and/or Orbitrap) is required. The successful candidate will work closely with medicinal chemists, structural biologists, biochemists and computational chemists to help early drug discovery projects.
Develop and implement various types of chemoproteomics methods to investigate small molecule-protein interactions including but not limited to targeted/non-targeted proteomics.
Develop and optimize sample preparation methods for bottom-up proteomics workflows.
Develop experiments to validate results from broad screening results.
Integrate into early drug discovery projects and provide covalent fragment screening hits.
Provide documentation, analysis, interpretation, and presentation of experimental data in a clear and concise manner.
Operate, maintain and troubleshoot LC-MS instrumentation in compliance with all safety rules and procedures.
Ph.D. in Biochemistry, Chemical Biology or from a related field with 2+ years of relevant experience or a MSc degree with 10+ years of relevant experience
Expertise in proteomics methods to analyze modifications on targeted or global proteins, including but not limited to tagging, derivatization, enrichment, MS/MS fragmentation, identification and quantification.
Hands on experience with proteomics data acquisition and interpretation including data processing, deconvolution, de novo sequencing.
Strong publication record demonstrating achievements and scientific productivity.
Ability to work in a fast paced environment with strong teamwork and communication skills.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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