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Principal Investigator, DMPK

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Our DMPK group is seeking a highly motivated and accomplished DMPK project lead to provide strategic DMPK support to the discovery and nonclinical development of small molecule and biologics drugs. The selected individual will be an integral project team member representing DMPK on small molecule and biologics research projects to ensure effective integration of ADME, PK and PKPD into the team strategy.
Job Responsibilities:
Serve as a DMPK project lead on discovery project teams. Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build thorough knowledge of drug candidate properties.
Be responsible for the design and interpretation of DMPK studies necessary for the selection of clinical candidates.
Ensure adequate characterization and liability assessment to support candidate nomination and clinical dose projections.
Responsible for writing PK reports, and author DMPK sections for regulatory submissions and IB updates.
Develop interdisciplinary collaborations and ensure that key DMPK data, information, and priorities are integrated into overall project team strategy.
Minimum Requirements
PhD or equivalent with 3+ years of industry experience in DMPK. Recent strong PhD graduate in a discipline relevant to pharmaceutical sciences will be considered.
A strong working knowledge of pharmacokinetics with hands on experience using PK software packages is preferred. Knowledge and expertise in modeling such as PBPK and PK/PD is a desirable plus. PK knowledge and experience on biologics is a plus.
A broad knowledge of clearance mechanisms of small molecule and biologics drugs is preferred.
Experience as a DMPK project lead in discovery programs is desirable plus.
Appropriate understanding of applicable FDA and European regulations with experience in IND filing and clinical protocols is a plus
Excellent oral and written communication skills are essential along with strong organizational skills.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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Job Posting: 1034838

Posted On: Sep 09, 2022

Updated On: Oct 09, 2022