Research Investigator, Structural Biology/Scientif

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Incyte is searching for a skilled structural or computational biologist, who is interested in working with biochemists, medicinal chemists, and computational chemists to enable structure-based drug design and elucidation of molecular mode of action of drugs. The selected applicant will play an integral role as part of the Structure Biology team in collaboration with Scientific Computing & Data Logistics within Incyte Discovery-Applied Technology Group. She/he will have exposure to cutting-edge technologies used to enable discovery including CryoEM/cryoSPARC/Relion, MOE/PSILO, Phenix, and CCP4, as well as investigate the potential to coupling the more traditional crystallographic methodologies with the latest in predictive technologies and artificial intelligence.
Responsibilities include (but not limited to):
Enhance the structural biology pipeline particularly for cryoEM
Support the development of both smallmolecule and protein-based biomolecules
Utilize modeling and protein engineering techniques to optimize current leads
Implement, vet, and apply machine learning/deep learning to supplement data gaps and help to understand complex processes that cannot readily be solved by current technologies
Integrate and augment internal experimental data workflows with public data and advanced analytical tools in AWS cloudbased environments.
Minimum requirements:
PhD in macromolecular crystallography, computational biology or related field with a minimum of 2 years experience
Proficiency in cryoEM experimentation and data analysis
Ability to work in a multidisciplinary team environment
Strong oral and written communication skills
The incumbent must be selfmotivated, detail-oriented, well-organized, and have a desire to integrate tools and concepts between the fields of structural and computational biology
Record of scientific accomplishments in the field of structural biology and computational biology
Preferred requirements:
Expertise in Xray crystallography techniques
Experience with protein predictive modeling and docking
Experience with SECMALS for protein characterization
Experience in Linux, Oracle, and coding in at least one highlevel language: python, java, etc
Experience with macromolecular predictive modeling: AlphaFold, RosettaFold, other similar packages.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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Job Posting: 1017859

Posted On: Aug 10, 2022

Updated On: Sep 01, 2022