Research Scientist/Sr. Research Scientist, Transla

at Incyte Corporation in Wilmington, Delaware, United States

Job Description

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Translational Sciences at Incyte has been established to bridge the research findings at the Discovery and Development levels within each of our clinical programs. In collaboration with academic, clinical and industry scientists, this group develops knowledge around each of our existing programs to enable clinical evaluation of target modulation, biological changes that correlate with target modulation, as well as biomarkers or patient characteristics that could be utilized to predict response to therapy. The results are used to enrich and refine the Development program strategy as well as inform and guide future Discovery efforts.
Summary (Primary function)
The Research Scientist/Sr Research Scientist, Translational Sciences (TLS), will develop and implement specialized molecular, cellular and biochemical assays to support specific portfolio related hypotheses and biomarker development. We are looking for a highly motivated scientist to work in a collaborative laboratory environment to discover and develop robust biomarkers for use in human clinical studies.
Essential Functions of the Job (Key responsibilities)

Develop, optimize, and qualify pharmacodynamic and target engagement biomarker assays.

Independently manage workload across multiple projects while effectively aligning resources based on key priorities.

Assimilate data and insight in real-time to recognize when an experimental approach needs to be adjusted/changed to deliver optimal results.

Troubleshoot and overcome complex problems in specialized procedures.

Incorporate proper quality controls and best practices to produce high-quality work.

Keep current with emerging trends in scientific discipline.

Understands the role of other functional areas in the laboratory and partners with them to maximize best practices and laboratory efficiencies.

Follow company safety practices, including training, lab safety, and record keeping as appropriate.
Qualifications (Minimal acceptable level of education, work experience, and competency)

Bachelor's Degree or equivalent education and typically 7 or more years of experience, Master's Degree or equivalent education and typically 5 or more years of experience.

Extensive experience in developing pharmacodynamics assays using flow cytometric analysis (FACs) to measure cell surface receptors (Receptor Occupancy assays) and phosphoproteins is required.

Proficient at FACS data analysis utilizing FACS Suite, FlowJo, Cell Engine or other flow cytometry software and scientific computer programs including Microsoft Excel, GraphPad Prism, and Spotfire.

Experience with Flow cytometry quality control assessments and routine instrument maintenance using accrediting agency standards and manufacturer specifications to assure the validity of laboratory results.

Hands-on experience with a wide range of cellular, molecular and biochemical assays, including, western blotting, ELISAs, MSD, Protein Simple ELLA, qPCR is required.

The successful candidate will have a solid scientific background with clear and concise verbal and written communication skills.

Possess a high level of critical thinking, high energy, independence, a strong desire to learn new techniques, and the ability to work in a highly dynamic research organization
Preferred Qualifications

Solid understanding of cancer biology and/or immuno-oncology is highly desirable.

Experience in primary human and mouse immune cell isolation, propagation, and immune cell-based functional assays.

Experience with lab automation or operation of liquid handlers.

Experience with automated DNA/RNA extraction along with appropriate QC methods.

Expertise in NGS library preparation and sequencing, most commonly RNAseq or 10X Genomics single-cell libraries, is a plus.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and... For full info follow application link.

We appreciate, celebrate, and thrive on one another’s differences and strengths and are proud to be an Equal Opportunity Employer. By valuing diversity of backgrounds and perspectives and prohibiting all forms of harassment, we are able to promote a collaborative and innovative work environment in which everybody can contribute to their fullest potential.        

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Job Posting: 1015334

Posted On: Aug 05, 2022

Updated On: Aug 17, 2022